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pentobarbital will lower the extent or result of cinacalcet by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.Contraindicated (1)pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can cut down panobinostat degrees by ~70%